A study by Oregon State University may have found a reason behind why some obese people develop type 2 diabetes but not all, indicating a difference in gene activity as well as modulation by a bacteria called Oscillibacter valericigenes (OV).
The team’s study suggests that the activity of a gene named Mmp12; a gene regulated by the microbiome in the gut and activated by consumption of a high-fat, high-sugar diet, is directly related to whether an obese person gets diabetes or not.
It is regulated by the microbe OV, which proliferates under a high-fat-high sugar diet and “causes an increase of insulin-resistant” fatty immune cells in the body….