I find it interesting that many post-COVID acute sequelae are occurring in those who have taken failed COVID-19 vaccines. We are a long way off from definitive clinical trials of multidrug strategies for patients who have had multiple exposures to the SARS-CoV-2 spike protein via vaccination or recurrent COVID-19. Kritis et al point out: “Curcumin (diferuloylmethane) is a natural phenol found in turmeric (Curcuma longa), a member of the ginger family of plants [4]. Curcumin modulates inflammation preventing the subsequent cytokine storm by inhibiting multiple transcription factors such as nuclear factor kappa B (NF-kB) and signal transducer and activator of transcription 3 (STAT-3), and downregulating the proinflammatory cytokines, as this has been demonstrated in human macrophages after influenza virus infection [4,6]. Additionally, curcumin inhibits ACE-modulating angiotensin II synthesis and downregulates inflammation, while it also promotes fibrinolysis and the anticoagulation process [4,6,7] (Fig. 1)….