The use of engineered nicotinamide adenine dinucleotide [NAD(H)], a molecule common to many animals, resulted in 100 percent sepsis survival in mice, creating a potential future treatment, a University of Wisconsin-Madison study has found.
Researchers from the study say the NAD(H) nanoparticles also have the potential to treat many other diseases because NAD(H) is involved with so many biological pathways.
The study found that a nanoparticle NAD(H) engineered with a fatty coat and molecular frameworks for stability, is able to treat sepsis by reducing leakage of fluid from blood vessels while also entering stressed cells directly to reduce inflammation….