Commentary Irvine, Calif. is the best large city in the state to open a new business, according to a new tabulation by financial website WalletHub. WalletHub considered the ecosystem, as local entrepreneurs call it, within 100 cities related to access to resources. It took into account access to financing, venture capital investment per capita, and the prevalence of investors. Other considerations included the availability of human capital, the quality of local colleges and universities, the share of the population who is college-educated, and the growth rate of the working age population. Irvine was the city with the most educated population. About 69 percent of its adult residents have at least a bachelor’s degree, more than double the national average of 32 percent. These factors were more than enough to make up for Irvine’s No. 97 placement on the list for business costs, ranking less expensive only than San Francisco (the …