Hypertension—high blood pressure—is closely related to the morbidity and mortality of cardiovascular and cerebrovascular diseases. In recent years, blood pressure monitoring and management have become more refined and individualized, but questions still remain about whether morning or evening is best to take antihypertensive drugs.
Substantial evidence suggests that nocturnal hypertension, increased morning blood pressure, and pre-morning hypertension are all associated with an increased incidence of cardiovascular disease. Many experts propose that blood pressure should be dynamically controlled 24 hours a day to reduce the adverse effects of nighttime high blood pressure. To achieve 24-hour BP control, administration of antihypertensive drugs at night or before bedtime is considered a potentially more effective strategy to control nocturnal hypertension, restore natural nocturnal BP drop, and suppress or eliminate morning BP spikes….