Why is the incidence of side effects from statins so low in clinical trials but appear to be so high out in the real world? There is now overwhelming evidence to support reducing LDL cholesterol—bad cholesterol—to reduce atherosclerotic cardiovascular disease, the number one killer of men and women. So, why is adherence to cholesterol-lowering statin drug therapy such a major challenge? The majority of studies reported at least 40 percent, and as much as 80 percent, of patients did not comply fully with statin treatment recommendations. Three-quarters may flat out stop taking them, or sometimes up to nearly 90 percent discontinue treatment….