Commentary In early 1918, when World War I entered its final year, the H1N1 influenza A virus infected millions of people, causing the Spanish flu pandemic. By April 1920, after four waves and almost 100 million deaths, the pandemic ended. H1N1 became much less deadly and caused only ordinary seasonal flu. It had become an endemic virus. Will history repeat itself? After two years of the COVID-19 pandemic and four waves of different variants, will SARS-CoV-2 become an endemic virus? Looking Good After my recent opinion piece “Omicron May Help End the Pandemic This Winter” was published, readers asked if I could cite peer-reviewed publications to support my pandemic-ending claim. Well, as the Omicron wave is still ongoing, my projection can only be as good as an educated prediction. But things are looking pretty good. In the past week, there have been a few related research works published that point …