An approved cancer therapeutic, once used in only 1 percent of cancers, may have significant uses in the remaining 99 percent, according to a new study.
“Ivosidenib, previously called AG-120, may be applicable to the large majority of cancers,” said senior author Dr. Jordan Winter, division chief of surgical oncology at University Hospitals Seidman Cancer Center in Cleveland.
Winter said that the therapeutic was previously used in the “1 percent” of cancers that carried a mutation, or change, in the IDH1 gene. However, scientists now believe it can also be used in the “remaining 99 percent” in cancer cells that carry the wild-type, or normal, IDH1 gene, under conditions that the environment is low in magnesium….