Since the discovery of DNA, the central dogma of genetic translation has lured us in with a simple path from genes to illness. With the completion of the Human Genome Project, however, we were forced to begin to explore the limitations of the mutation model of illness and our assumptions about the biology behind illness and health. Despite this sobering reality, and the history of genetic studies of depression coming up empty-handed, many of the 30 million people in the United States taking medication still believe that genes play a role in their “disease.” Frustration with the field’s current approach has been seeping into the industry. In 2017, Dr. Thomas Insel, former director of the National Institutes of Mental Health, said, “I spent 13 years at NIMH really pushing on the neuroscience and genetics of mental disorders, and when I look back on that I realize that while I think I succeeded …