P&O Ferries resumed sailings across the English Channel for the first time since the firm suspended most of its sailings on March 17 following the sacking of 786 seafarers.
Spirit of Britain departed the English port of Dover for Calais, France, shortly after 11 p.m. on Tuesday carrying freight customers, with passenger services expected to resume early next week.
The ship was detained by the Maritime and Coastguard Agency (MCA) on April 12 after safety issues were found, but was cleared to sail on Friday.
It comes as another P&O Ferries vessel undergoes reinspection after it lost power at sea on Tuesday.