Commentary More than twenty months into the pandemic, it’s clear that many mandated mitigation strategies do not significantly prevent virus transmission, or do so at a steep price. Lockdowns haven’t stopped virus spread around the world, and are not sustainable due to massive collateral damage. There is no consistent evidence of a benefit of universal masking, despite unprecedented politicization and potential for bias in scientific studies. School closures and remote learning are harmful and ineffective, as children remain at low risk for severe disease and schools are not major drivers of community outbreaks. Vaccines may limit severe disease, which is important for vulnerable individuals, but are less effective at preventing infection and transmission than immunity acquired by infection. Despite a lack of compelling evidence, many leaders continue mandating unproven and unnecessary restrictions on a COVID-fatigued population. However, amidst these failures, one effective COVID-19 mitigation strategy stands out—improving indoor ventilation. It was known quite early in the pandemic that outdoor transmission of SARS-CoV-2 was rare, and that indoor transmission …